We are developing a visual antibody-omics platform for direct, real-time visualization of the polyclonal antibody landscape. Using negative-stain electron microscopy (nsEM), we capture snapshots of antibody responses following vaccination or infection, generating semi-quantitative maps of epitopic diversity against defined immunogens. In SARS-CoV-2 studies, this approach reveals how antibodies targeting conformational non-RBD regions drive broad cross-neutralization across variants, while in influenza HA research, it uncovers how cross-reactive antibodies to conserved HA epitopes are shaped by pre-existing exposure. We are currently refining sample-preparation workflows and developing antibody subtype–specific analyses, advancing toward a more comprehensive and visual understanding of humoral immunity.