Dr. Yang ‘Renee’’s research focused on DNA self-assembly and immune response evaluation and modulation. She has developed site-specific and non-site-specific protein-DNA conjugation and assembly methods, which can arrange any proteins of interest with controlled position, ratio, and orientation on DNA scaffolds. With this method, Renee created artificial multi-enzyme DNA complexes and networks that addressed important fundamental enzymology issues related to multi-enzyme catalysis. Renee also used new principles and approaches for designing self-assembled catalysts that have broad applications in the production of high-value products in industry and bioenergy as well as diagnostic applications in biomedicine. During postdoc training, Renee solved high-resolution cryoEM structures of HIV surface protein and neutralizing antibody complexes, demonstrated the structural details, and revealed the molecular interactions at the ‘glycan hole’ epitope and explained why it is difficult to broaden, contributed to improving HIV vaccine design. Dr. Yang is continuing research in using DNA nanostructure as molecular scaffolds and develop next-generation vaccine and EM-based immune response evaluation platform.